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KMID : 0620920080400050558
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Experimental & Molecular Medicine
2008 Volume.40 No. 5 p.558 ~ p.564
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Heritability and linkage study on heart rates in a Mongolian population
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Bayasgalan Gombojav
Ohrr Hee-Choul
Seo Jeong-Sun
Kim Jong-Il
Park Han-Soo
Ju Young-Seok
Sung Joo-Hon
Cho Sung-Il
Lee Mi-Kyeong
Janchiv Radnaabazar
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Abstract
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Elevated heart rate has been proposed as an independent risk factor for cardiovascular diseases, but their interrelationships are not well understood. In this study, we performed a genome-wide linkage scan in 1,026 individuals (mean age 30.6 years, 54.5% women) from 73 extended families of Mongolia and determined quantitative trait loci that influence heart rate. The DNA samples were genotyped using deCODE 1,039 microsatellite markers for 3 cM density genome-wide linkage scan. Correlation analysis was carried out to evaluate the correlation of the covariates and the heart rate. T-tests of the heart rate were also performed on sex, smoking and alcohol intake. Consequently, this model was used in a nonparametric genome-wide linkage analysis using variance component model to create a multipoint logarithm of odds (LOD) score and a corresponding P value. In the adjusted model, the heritability of heart rate was estimated as 0.32 (P＜.0001) and a maximum multipoint LOD score of 2.03 was observed in 77 cM region at chromosome 18. The second largest LOD score of 1.52 was seen on chromosome 5 at 216 cM. Genes located on the specified locations in chromosomes 5 and 18 may be involved in the regulation of heart rate.
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KEYWORD
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cardiovascular diseases, chromosome mapping, genomics, heart rate, Mongolia
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